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The Enzyme That Breaks Down Histamine*
Solaray DAO Enzyme includes 4.2 mg of diamine oxidase (DAO) per serving, supplying 60,000 histamine degradation units (HDUs) that help the body break down, or metabolize, histamine.* This high-quality supplement is produced in our GMP facility that is certified by NSF, with ingredients that are triple-tested to meet strict guidelines on potency, purity, and contaminants.**
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Get mealtime support when you need it from DAO, the enzyme that breaks down histamine.* This powerful formula contains DAO from pea sprouts, protected by our Enteric Shield VegCaps to ensure its 60,000 histamine degradation units (HDUs) reach your gut.*
Diamin Oxidase (from Pea Sprout) (Supplying 60,000 HDU), Cellulose, Vegetable Cellulose Capsule, Silica.
Use only as directed. Take 1 VegCap three times daily. Store in a cool, dry place.
This plant-based DAO enzyme supplement helps the body break down histamine as you navigate the foods that are right for you.*
Since 1973, Solaray has believed that what you put in your body should be proven, not promised.
We source our own raw materials and triple-test every lot.
We manufacture 95% of our products for full control.
15,000 tests per month verify ingredient potency and purity.^
In an industry where quality can vary widely, testing isn't just a step in the process. It is the process.
✅ Passed Testing for Heavy Metals**
Arsenic, cadmium, lead, mercury
✅ Passed Testing for Microbials**
Mold, yeast, coliform, e. Coli
✅ Passed Testing for Contaminants**
Gluten, ethylene oxide
✅ Passed Testing for Physical Properties
Moisture, color, disintegration, tap density, mesh 140, 20, and 60
**Most contaminants, heavy metals, and microbes are tested to ensure no more than 3 ppm.
Our production facility in Ogden, Utah is a GMP facility certified by NSF. We source and triple-test raw materials, make the majority of our products in-house, conduct stringent testing in our ISO-accredited lab, and distribute our own products to ensure quality and excellence in every bottle.
The enzyme that breaks down histamine.*
The recommended dosage of this carefully formulated supplement is 1 VegCap three times daily, delivering 4.2 mg of diamine oxidase (DAO) per serving.
Research often recommends taking DAO Enzyme around 15 minutes before a meal to support dietary histamine breakdown. You can take DAO before a meal up to three times per day.
In general, most people feel some benefits of DAO Enzyme within a few weeks when the full dose is taken 15 minutes before a meal for at least 14 days, depending on individual health status.*
Research indicates a link between histamine intolerance concerns and low DAO activity. To determine how much DAO is naturally present in your gastrointestinal tract, a blood test can be used to check your DAO enzyme levels.
To check your DAO level, contact your healthcare provider to schedule a blood test that measures serum DAO concentration.
Alcohol and foods that are high in histamine, such as fish, mature cheeses, cured meats, and some fruits and vegetables, have been linked to inhibited DAO activity. See question 4 for a more detailed list of foods with high histamine content.
Foods with high histamine content include wine and beer, fish (especially canned fish products and fatty fish like tuna, salmon, or mackerel), matured and semi-hard cheeses, cured meats, citrus fruits, strawberries, and some vegetables including tomatoes, sauerkraut, and spinach.
DAO enzymes are naturally present in the gastrointestinal tract. A supplement containing diamine oxidase (DAO) can introduce additional DAO enzymes that help the body break down histamine.
Overall rating: 4.928571 / 5 from 14 reviews.
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"I have terrible allergies and have yet to fully suppress them, but this enzyme (paired with antihistamines and other supplements) has made this past allergy season bearable. It has now become a part of my year round routine even when I go off of the antihistamines."
— Michelle W. (5/5)
"Has helped my histamine issues dramatically!"
— Melodie T. (5/5)
"This has been an absolute lifesaver for me dealing with histamine imbalance/gut imbalance. Will forever use this product!"
— Damara R. (5/5)
"I’ve used this product for about a month now and while more experience will give me a better idea of how useful it is, having used it for this month I already sent a difference in how I feel in response to histamines. Ordering it from Solaray was as easy as could be."
— Lavey D. (4/5)
"Has been a key part of a regimen that has greatly improved my digestive health."
— Molly K. (5/5)
"The vegan DAO enzyme works so well compared to animal version"
— Emily G. (5/5)
"I'm pleased with my purchase."
— Vivian D. (5/5)
"Excellent quality. So greatful for this product!!!"
— Shyanne T. (5/5)
"Hi, my doctor suggested a form of DAO as I tested very high histamine. I suffer from celiac and fibromyalgia. So far I've taken this for a couple of months. I feel a little relief in my allergies but not significantly better yet. Maybe the 6 month marker will tell. It is pricey but worth it to feel better. I've taken exactly as directed. I hope this helps."
— Rachel R. (5/5)
"Perfect for when we go eat at our local taco place and feel awful after eating the cheese. No more suffering from a histamine reaction as this takes care of it right away."
— Leigh (5/5)
Disclaimer: The customer reviews and testimonials featured on this site reflect individual experiences and opinions. Results may vary and are not guaranteed. These statements have not been evaluated by the Food and Drug Administration (FDA). The content is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any new supplement regimen or if you have concerns about your health.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.