GLP-1 medications have transformed the landscape of weight management in the United States. By slowing gastric emptying and reducing appetite, these medications help users feel fuller longer and consume fewer calories—an effective strategy for weight loss and blood sugar control.
With reduced food intake comes a new challenge: ensuring your body still gets the essential nutrients it needs to thrive. Some GLP-1 users may experience unintended nutritional gaps, often in key vitamins and minerals like B12, D, calcium, and magnesium.1 Others may need additional support for digestion, regularity, and maintaining a healthy microbiome.2,3 That’s where targeted supplementation, in consultation with your healthcare provider, can help.
In this post, we’ll explore how trusted supplements can help fill nutritional gaps, support gut health, and keep your wellness journey on track.* Whether you're just starting a GLP-1 medication or looking to optimize your routine, these insights will help you make informed, supportive choices for your body.
How GLP-1 Medications Work
GLP-1 medications—short for glucagon-like peptide-1 receptor agonists—are a class of drugs originally developed to treat type 2 diabetes. Today, they’re also widely prescribed for weight management because of their powerful effects on appetite and metabolism.
These medications mimic the body’s GLP-1 hormone, which is released by the gut after eating. Once activated, GLP-1 receptors in the pancreas and brain trigger a cascade of effects: they stimulate insulin production, suppress glucagon (a hormone that raises blood sugar), and slow gastric emptying. The result? You feel fuller longer, eat less, and maintain more stable blood sugar levels.4
As these medications reshape how we approach weight and metabolic health, it’s important to understand not just how they work—but how to support your body while taking them. That’s where targeted nutrition and supplementation come in.
Digestion Support + Probiotics for GLP-1 Users*
Gut health plays a pivotal role in the GLP-1 weight management journey. These medications work by slowing gastric emptying and reducing appetite—mechanisms that support weight loss but may also impact digestive regularity and microbiome balance. That’s why Solaray is committed to supporting GLP-1 users with supplements designed to support digestion and a healthy microbiome.*
For regularity and digestion, our fiber powders are a simple, effective way to support your wellness while taking a GLP-1 medication.* Whether stirred into water or blended into a smoothie, psyllium husk fiber is a popular source of soluble fiber traditionally used to support digestive health and regularity.* Solaray’s Psyllium Husk Fiber also delivers cardiovascular support so you can stay supported as you exercise more.*
For microbiome health, Mycrobiome Complete Active is an expert-formulated, triple-action probiotic that delivers targeted digestion, cardiovascular, exercise, and respiratory support, plus support for fat loss.*^ This 3-in-1 pre, pro, and postbiotic features clinically studied ingredients and an expert combination of strains to nurture the entire probiotic life cycle for powerful support.* It is protected by Enteric Shield® VegCaps, which are designed to help protect the probiotics from harsh stomach acid and help them arrive alive in the intestines for optimal delivery. The Mycrobiome Complete line also includes targeted formulas for women, men, adults 50+ and more.
Akkermansia is another powerful option to support your microbiome. This trending postbiotic bacterium is important for gut health, and our forward-thinking formula delivers a potent dose of this novel strain.* This next-generation beneficial postbiotic is carefully crafted to support microbiome health and provides shelf-stable gut health support on the go.*
^In conjunction with a healthy diet and exercise.
Bridging the Vitamin Gap for GLP-1 Users
GLP-1 medications work by reducing appetite and slowing digestion—two mechanisms that help users feel fuller longer and consume fewer calories. While this is a powerful tool for weight management, it also means that some users are eating significantly less food. Over time, this reduction in food intake may lead to lower levels of essential vitamins and minerals, especially if meals are less nutrient-dense or entire food groups are avoided.
GLP-1 medications may also impact how the body absorbs certain nutrients. Research indicates that vitamins B12 and D are of particular concern when it comes to nutrient absorption.1 To help bridge these nutritional gaps, Solaray offers several vitamins that can help support your GLP-1 routine.
Liposomal multivitamins for women and men are designed for optimal absorption and deliver a high-potency blend of more than 30 liposomal nutrients—with most vitamins and minerals at 100% of the Daily Value or more. This gentle-to-digest formula can be taken with or without food, so you can stay consistent with your multivitamin routine even while you’re eating less.
A healthy immune system and strong bones are important while you’re keeping up with a regular exercise routine. Vitamin D3 K2 provides powerful immune support as well as support for healthy bones.* D3 also supports the absorption of calcium, which is important as you exercise more often.*
You’ll want to keep your B12 levels in the healthy range while you’re taking a GLP-1 medication. Vitamin B12 is a water-soluble vitamin that supports proper nerve function and cellular energy metabolism.* It cannot be stored in the body, which means you may need a supplement to help maintain adequate levels.
Mineral Supplements for GLP-1 Users
Because GLP-1 medications reduce appetite and food intake, some users may unintentionally consume fewer essential nutrients—especially if dietary variety or quality is compromised.
Magnesium, calcium, potassium, and zinc play a critical role in everything from healthy muscles to strong bones, which are especially important when you're staying active as part of your routine.* Solaray’s mineral supplements are designed to help fill those gaps with formulas that support your body’s foundational needs.
Magnesium glycinate delivers potent muscle, bone, and relaxation support to help you feel your best while exercising and recouping afterwards.* Solaray’s award-winning supplement includes black pepper extract to aid in gentle digestion.
For bone strength support, turn to calcium citrate.* Our formula includes an herbal base of watercress leaf, dandelion root, and parsley leaf for additional nutritive support.*
Collagen Bone Complete is an award-winning blend of vitamins and minerals plus collagen that delivers powerful bone support to help you feel and function at your best while you’re taking GLP-1 medications.*
Solaray is Here for Your GLP-1 Journey
We understand that every GLP-1 journey is personal, and that progress starts with daily habits that turn into lifelong routines. That’s why we’re here to support you with trusted supplements designed to help you feel your best from the inside out.
Whether you’re navigating digestive changes, filling nutritional gaps, or staying strong through movement, our triple-tested formulas are crafted to meet your evolving needs.
Wherever you are on your path, Solaray is here to help you stay nourished, resilient, and empowered—every step of the way.
Resources:
1 Johnson B et al. Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study. Sec. Clinical Nutrition. 2025 April 24. Volume 12 - 2025.
2 Filippatos TD, Panagiotopoulou TV, Elisaf MS. Adverse Effects of GLP-1 Receptor Agonists. Rev Diabet Stud. 2014;11(3-4):202-230. doi:10.1900/RDS.2014.11.202
3 Zeng Y, Wu Y, Zhang Q, Xiao X. 2024. Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases. mBio 15:e02032-23. https://doi.org/10.1128/mbio.02032-23
4 “GLP-1 Agonists” Cleveland Clinic. my.clevelandclinic.org/health/treatments/13901-glp-1-agonists.
5 Kanai R et al. Once-weekly semaglutide administered after laparoscopic sleeve gastrectomy: Effects on body weight, glycemic control, and measured nutritional metrics in Japanese patients having both obesity and type 2 diabetes. Obes Pillars. 2024 Jan 3;9:100098. doi: 10.1016/j.obpill.2023.100098. PMID: 38230266; PMCID: PMC10789635.